This is perhaps the most bizarre, beautiful and creative film ever made.  The cinematography, costuming (by Jean-Paul Gaultier), set design, music, special effects and performances by all actors are all absolutely superb.  Another fantastic movie by Jean-Pierre Jeunet and Marc Caro, the creators of Delicatessen, Alien Resurrection, and other brilliant work. 

'Ones'  best friend is murdered, and later that same night his adopted little brother 'Denre' is kidnapped by a cult organization nicknamed 'The Cyclops' in the search for his little brother One links up with 'Miette' , a beautiful and charismatic orphan, who works with other orphans stealing money and valuables for two siamese twins collectively nicknamed 'The Octopus' (on account of the total number of limbs between them).  Together, as they forge a beautiful friendship, they unravel the mystery of the many missing children, and their connection to a mysterious structure off the bay of the strange metropolis they live in.  In this strange building live a group of engineered humans, who perform bizarre experiments.